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Oakley AJ, Harnnoi T, Udomsinprasert R, Jirajaroenrat K, Ketterman AJ, Wilce MCJ

Genome-wide methylation comparisons between 65 DS and 59 NS healthcare workers revealed 21 loci in circadian genes, including PER3 and CSNK1E, to be significantly hypomethylated among NSW, highlighting potential epigenetic mechanisms underlying shift work-associated disease risk 214

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Potential Interactions General Dosing Recommendations Aside from the interaction between vitamin C and vitamin B12 stated above, the two groups are unlikely to interact

Many users find once-daily dosing more sustainable over multi-week protocols