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Rotate injection sites to prevent lipohypertrophy, which is the buildup of fatty tissue from repeated injections in the same location
Ferrucci, C
NICE and BNF Guidance: You correctly point out that even official guidance from NICE and the BNF acknowledges that some individuals may require more frequent injections
Forgetting dose floors: The calculator always floors the number of doses per vial to avoid overestimating
The main rationale for cycling rather than continuous use involves conservative safety practices given limited long-term human data, cost management, and theoretical concerns about receptor desensitization with extended exposure
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