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Davies MJ, Aroda VR, Collins BS, Gabbay RA, Green J, Maruthur NM, et al

IGF-1 LR3s ability to cross the blood-brain barrier (reported in some animal models, though this is dose and model dependent) has made it a tool for examining central nervous system IGF1R effects

This process shifts the chemical equilibrium toward the formation of the active VQ species and prevents the reverse reaction, thereby bypassing what was previously the rate-limiting elimination step