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The FDA has given tirzepatide Fast Track designation for reviewing it for treating excess weight
Patients reporting "significant energy improvement" rate injections as worth the cost at 2.4x the rate of those reporting "mild improvement." Comparison to alternatives: MIC B12 injections occupy a middle ground: more effective than oral supplementation for B12 repletion and subjective energy, less effective than prescription weight-loss medications for weight reduction, and significantly less expensive than GLP-1 agonists
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Watch for severe abdominal pain, persistent diarrhea or constipation lasting more than a week, inability to keep food or liquids down, or signs of dehydration
In the study, participants who received supervised exercise instruction maintained a weight loss of at least 10% of initial body weight one year after treatment termination compared with those who received liraglutide alone or placebo (4)
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