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3.4.3 Weight changes Concerning weight change, Tirzepatide did not demonstrate clear superiority over Semaglutide, with a pooled effect size of 2.57 (95% CI: 6.771.62
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That doesnt mean you should start with such doses, as it may lead to serious gastrointestinal reactions, like nausea, stomach pain, diarrhea, and gastritis (inflammation in the stomach lining), if you dont increase gradually to higher doses
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