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The STEP 4 trial demonstrated that participants who discontinued semaglutide after 20 weeks regained approximately two-thirds of lost weight over the next 48 weeks
These incretin-based medications work by mimicking naturally occurring hormones that enhance insulin secretion, suppress glucagon release, slow gastric emptying, and reduce appetite through central nervous system pathways
nevertheless, NAION is often irreversible and can be devastating in specific risk groups (patients with monocular vision or prior NAION in the fellow eye), in which even a small excess risk matters for clinical decision-making [3436,3840]
The results of the study showed a similar number of cases of depression among GLP-1RAs and SGLT2is
Body composition assessment requires different tools: DEXA scans, bioelectrical impedance, or at minimum, waist circumference measurements
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