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5.1.1 Potential implication in PTC clinical management Preclinical studies and emerging clinical evidence suggest that DPP-IV inhibitors may exert direct anti-tumor effects in PTC (Lee et al., 2017)

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Human embryonic kidney 293 cells containing SV40 large T-antigen (HEK293T) were cultured in DMEM (Gibco) supplemented with 10% (v/v) fetal bovine serum (FBS, Gibco), 1 mM sodium pyruvate (Gibco) and 100 units/mL penicillin and 100 g/mL streptomycin at 37 C in 5% CO 2

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