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Final thoughts In our opinion, the rise of peptide-based skincare signals a major shift in how we approach anti-aging treatments

In one hand, in HIV-1 fusion, the transmembrane subunit gp41 from HIV-1 envelope glycoprotein mediates fusion of the virus with the target cells and both oleuropein and HOTYR are also able to inhibit the fusion promoting refolding of gp41

The DAC modification adds the albumin-binding layer on top of this enzymatic protection

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It has also been reported that the presence of the CH=CH-COOH group has a highly positive effect on anti-AChE activity compared to the CH 2 -CH 2 -COOH or COOH group (Szwajgier, 2013), which is also consistent with the structures of the active inhibitory phenolic compounds in our screening