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Spencer Nadolsky, an obesity physician who treats GLP-1 patients, tells Yahoo

Nguyen NH, Ohno-Machado L, Sandborn WJ, Singh S

For example, if you were stable at 1.7 mg and took a three-week break, your provider might suggest restarting at 1 mg for one or two weeks, then returning to 1.7 mg

Always read at eye level, using the bottom of the meniscus as your reference point

Regain begins within 2 to 3 weeks of last dose Appetite returns to pre-treatment levels or higher (rebound hyperphagia) Weight regain of 1 to 2 pounds per week for the first 8 to 12 weeks Patients report feeling "more hungry than before I started" Typically occurs in patients who made minimal dietary or behavioral changes during treatment Regain trajectory matches or exceeds the STEP 1 extension trial data (two-thirds of weight back within one year) Pattern 2: Partial regain with stabilization (approximately 45% of discontinuations)