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Predicted properties of natural homologues As described in the main text, we used our multi-task neural-network ensemble model to make predictions for natural GCG and GLP-1 peptide orthologues that are found in various organisms, identified using BLASTp to search the NCBI RefSeq 49 database to identify non-redundant proglucagon sequences from various organisms across diverse phylogenetic groups
26 Lixisenatide FDA product information (2023)
When bound to these receptors, the action of GLP-1 antagonist has the following effects: Stimulates the production of insulin Reduces glucagon production in the liver Signals to the brain a feeling of fullness Slows the rate of gastric emptying This results in: Better regulation of blood sugar levels Reduction of appetite Reduction of food intake Weight loss In other words, patients get full quickly, stay full longer, and rarely have food cravings or hunger
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