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The mechanism is multifactorial: weight loss reduces the mechanical load on the cardiovascular system, improved insulin sensitivity reduces sodium retention, and direct vascular effects of GLP-1 receptor activation promote vasodilation
Some trial participants stopped retatrutide early because they had lost too much weight
Uptake in Britain is expected to rise further with the arrival this week of GLP-1s in pill form, with UK pharmacies preparing for a rise in requests for the once-a-day Wegovy tablet now only available on private prescription
The GLP-1 receptor activation enhances insulin secretion and reduces appetite
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