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Retatrutide activates three hormone receptors: GIP (glucose-dependent insulinotropic polypeptide), GLP-1 (glucagon-like peptide-1), and glucagon receptors
Obese and lean mice were given either saline, AOD9604, or hGH through an osmotic pump over the course of 14 days
The combination has not shown any emergent toxicity beyond what would be expected from either peptide individually
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In practice, the human protocols that have emerged in clinical and sports medicine settings cluster in the range of 200 to 600 micrograms per day, sitting conservatively within that broader range
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