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Collectively, these findings have provided broad support for the development, use, and safety of GLP-1 therapeutics in human subjects with diabetes and obesity, and have identified new disease areas (NASH, CNS disorders such as Parkinsons and Alzheimers disease) that may benefit from therapy with GLP-1R agonists

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Among the NK cells subset, CD56 dim PC-phospholipase C bright cells are associated with cytotoxic function, whereas CD56 bright PC-phospholipase C low/- cells exhibit immunoregulatory properties (133) ( Figure 3 )

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The and classes of GSTs play a regulatory role in the mitogen-activated protein (MAP) kinase pathway that participates in cellular survival and death signals via protein : protein interactions with c-Jun N-terminal kinase 1 (JNK1) and ASK1 (apoptosis signal-regulating kinase)