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What Does the Broader Research Say
Extended-release niacin formulations may cause less glucose elevation than immediate-release products but carry a higher risk of hepatotoxicity
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Nevertheless, the target for GIPR antagonists is believed to be a neuronal population in the brain, as a peptideantibody conjugate that blocks GIPR while activating GLP-1R required central GIPR for maximal weight loss in DIO mice, as determined using mice lacking Gipr in cells expressing synapsin 12
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