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One filing referenced distributors listing the drug as out-of-stock or available only in limited quantities, suggesting gaps in the supply chain despite the FDAs confidence in Eli Lillys manufacturing capacity
Most GLP-1 receptor agonists (except exenatide formulations) carry an FDA boxed warning regarding thyroid C-cell tumors observed in rodent studies and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
MC4R is also known to be important for appetite control in humans
I., Paley, C
While most side effects are mild and temporary, their severity and frequency vary depending on an individuals health status, dosage, and response to treatment
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