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SULT Polymorphisms SULT1A1 has a common variant, Arg213His (rs9282861), that reduces enzyme activity and thermal stability

In a six-month trial of patients with primary biliary cholangitis, daily doses of 500mg, 1000mg, or 1500mg of TUDCA shifted bile composition toward more hydrophilic bile acids, including higher UDCA levels a profile believed to be less toxic to liver cells.31 Overall, TUDCA has been shown to improve blood tests linked to bile buildup, but it hasnt yet been proven to prevent cirrhosis or improve long-term survival

Avoid self-medicating with OTC drugs or supplements without consulting your doctor

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Your provider determines the schedule based on your labs and response