What Clinical Trials Report About Abdominal Pain The Phase 2 trial (Jastreboff et al., NEJM 2023, n=338) provides the most detailed published data on retatrutide-related stomach pain
Most patients notice reduced appetite within the first few days, with visible weight loss starting in a few weeks
The study notes that the amount of decrease in Lp(a) is similar to that of using niacin or a PCSK9 inhibitor.[ref] Coconut oil instead of omega-6 oils: An intervention study looking at fat in the diet found that a diet high in saturated fat from coconut oil decreased Lp(a) by 17 mg/L, while a diet high in polyunsaturated fatty acids increased Lp(a) by 25 mg/L.[ref] High phenol olive oil: A small clinical trial showed that high phenol olive oil or large quantities of low phenol olive oil lowered Lp(a) levels a bit.[ref] Lowering cholesterol: Overall, lowering your LDL cholesterol numbers can help lower Lp(a) since Lp(a) is the carrier for LDL
In addition, the weight loss associated with these molecules has recently extended their indication to the treatment of obesity
As a result, ABCA1 expression increases, promotes cholesterol outflow and reduces cholesterol-induced cytotoxicity
