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For one, Wegovy is given as a weekly injection under the skin, while Contrave is an oral tablet
Indeed, N-acetylgalactosamine-conjugated siRNA targeting AGT was highly effective in suppressing circulating AGT, thereby reducing blood pressure as ACE-inhibitors (ACE-i) and angiotensin-II receptor blockers (ARBs) (45)
GHK-Cu has the stronger published research footprint because it is a specific peptide-copper complex
A larger follow-up RCT (n=72 older adults) confirmed these findings, additionally demonstrating improvements in gait speed (+0.14 m/s), grip strength, 6-minute walk distance, waist circumference reduction, and systolic blood pressure reduction (Kumar et al., J Gerontol A Biol Sci Med Sci, 2023) [21]
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