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It is FDA-approved for chronic weight management in eligible adults when used with a reduced-calorie diet and increased physical activity

The involvement of a high dietary intake of methionine-rich animal proteins has not yet been investigated and cannot be ruled out

Additionally, chronic use can lead to vitamin b12 deficiency, which may require supplementation

The percentage of patients who achieved a clinically meaningful treatment response (defined as achieving at least 5% weight loss after 1 year of treatment) ranged from 36% to 57% with CONTRAVE, compared to 17% to 43% with placebo

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