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Recent reports demonstrated that GSH depletion triggers ferroptosis in some cell types 18

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KluzaKZawlikIJanowskaMKmieAPaszekSPotockaNet al

The company said in January that it expected approval in the second half of 2025, but it cautioned that it would not be able to commercialize the drug before Novo's patent expires in 2026, unless a Chinese court makes a final ruling that the patent is invalid

Although found tethered to the apical (luminal) membranes of capillary endothelial cells, the endothelial cells themselves do not synthesize the enzyme