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Chan JCN, Paldnius PM, Mathieu C, Stumvoll M, Matthews DR, Del Prato S (2021) Early combination therapy delayed treatment escalation in newly diagnosed young-onset type 2 diabetes: a subanalysis of the VERIFY study

While we never recommend crash dieting, we do recommend maintaining a calorie deficit, which means consuming fewer calories than you burn

An inducer of NLRP3 activation is the disassociation of thioredoxin-interacting protein (TXNIP), an intracellular redox regulator that inhibits antioxidants, from TRX (thioredoxin), a redox protein, via ROS or oxidative stress (122, 124)

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In reality, weight gain and loss are far more nuanced