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Your body needs time to get used to the medicine, which is why doctors recommend slowly increasing the dose gradually over the course of several months, which is known as a titration schedule
Obes Med 46:100533 Dutta D et al (2024) Glucagon-like peptide-1 receptor agonists in post-bariatric surgery patients: a systematic review and meta-analysis
Because Retatrutide adds glucagon receptor activation that Tirzepatide does not include, there may be new GI adjustment during the transition even if you tolerated Tirzepatide well
doi:10.3390/ijerph18042177 Duedahl-Olesen L, Ionas AC
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