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00:03:46 And I was a little bit, my wife goes, yeah, you're the one person on the earth that like, he should know that like, you're so like that
Because retatrutide includes GLP-1 agonism (which semaglutide was providing) plus GIP and glucagon agonism, the transition should not result in loss of appetite suppression during the switch
Both agents require careful patient selection and monitoring, particularly in patients with pre-existing medical conditions that may be affected by their mechanisms of action
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