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The body has a limited number of hormone receptors
This ability to prevent nausea is crucial as it helps patients stick to chemotherapy treatments without being burdened by debilitating sickness
Related expressional change of HIF-1 to the neuroprotective activity of exendin-4 in transient global ischemia
J Pharmacol Exp Ther 329(1):102111
The figure connects the activation of GLP-1R to downstream pathways (cAMP/PKA, Epac/PI3K/Akt, AMPK/SIRT1, ERK/MAPK) that regulate mitochondrial function, autophagy, proteostasis, and stress response, all of which collectively influence the hallmarks of aging to improve both cellular and systemic resilience
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