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Adequate hydration and fiber intake help manage the constipation that sometimes occurs with these medications
3 To help guide dosing decisions, use the estimated glomerular filtration rate (eGFR) instead of the serum creatinine (SCr) level, because the SCr can translate into a variable range of eGFRs ( TABLE 1 )
If you do experience weight loss and have piles, it is better to get a colonoscopy done to rule out other medical complications.
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Identifying the receptor would enable structure-activity relationship optimization
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