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Gene expression analysis revealed Clock expression in leukocytes decreased 1.8-fold, Cry2 expression doubled, and Csnk1e expression in lymphocytes decreased 2.1-foldall statistically significant changes indicating re-entrainment of disrupted circadian oscillations

The rate-limiting step is blood flow to the injection site

doi:10.1016/j.ejim.2011.11.013 Guilliams, Thomas G, and Lindsey E Drake