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Durando M, Tiu H, Kim JS
Factors associated with impaired cerebrovascular reactivity and neurovascular coupling include cerebral microvascular dysfunction, insulin-like growth factor 1 (IGF-1) deficiency, and oxidative stress-related inhibition of neuronal and astrocytic vasodilators (Phillips et al., 2016
Changes usually appear gradually and naturally, with skin looking fresher, more even, and healthier over time
consult a doctor for medical advice
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