Overall, across PBMs the consensus access policy is very tight : PBMs uniformly require prior authorization for GLP-1s used for obesity, almost always mandate step therapy, and site-of-care is typically limited (e.g
found that fast escalation to 8 mg produced GI adverse events in 50% of participants, compared to roughly 35% with gradual titration (Rosenstock et al., Lancet, 2023)
It's also obviously an unfair advantage in sports and, like other kinds of steroids and doping, is thoroughly banned
107 Interestingly, only an estimated 15% of the active GLP-1 reaches the portal vein before the liver, due to the rapid inactivation through DPP-IV
GSH availability down-regulates the pro-inflammatory potential of leukotrienes and other eicosanoids