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Additionally, mitochondria release apoptosis-inducing factor (AIF) and endonuclease G (Endo G), which mediate caspase-independent apoptosis (Joza et al., 2001)
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doi: 10.3389/fncel.2022.1067570 Received 12 October 2022 Accepted 13 December 2022 Published 11 January 2023 Volume 16 - 2022 Edited by Zhen-Ni Guo, First Affiliated Hospital of Jilin University, China Reviewed by Frederick Colbourne, University of Alberta, Canada
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This sparked further advancements, including Novo Nordisks development of more potent analogs like liraglutide and semaglutide, with the latter achieving over $12 billion in sales by 2022
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