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Psychological Effects Some patients report psychological side effects, such as: Anxiety Depression Mood swings It is important to monitor any changes in mood and seek support if psychological side effects occur

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If you develop diarrhea while on Linzess, use a backup method of birth control and discuss your symptoms with your healthcare provider

This is why patients experience severe post-exertional malaise (PEM)their cells literally lack the energetic currency required to recover from even minor physical or cognitive exertion

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