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Meaningful weight loss typically becomes visible by weeks four to six

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3) Are there any exceptions

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Clinical trial data is missing

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In their respective Phase 3 obesity trials tirzepatide reached roughly 2022.5% and semaglutide 2.4 mg about 14.9%, compared with retatrutides 28.3% at 12 mg though these are separate trials and not head-to-head

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doi: 10.1016/j.jhep.2019.09.031 27 LiYMaSTangLLiYWangWHuangXet al

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