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Single-compound approaches often target only one aspect of the repair cascade local fibroblast proliferation, systemic cell recruitment, angiogenesis, or inflammation suppression

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Initially focused on metabolism, research showed NNMT elevation with age/weight leads to fat accumulation, inefficiency, and NAD+ loss.[30][31] High NNMT correlates with insulin resistance and obesity in humans

Macrophage depletion can reduce inflammatory cytokines and trigger adiponectin secretion from both SAT and VAT adipocytes, leading to the induction of preadipocyte differentiation in SAT, but not VAT

According to the National Institutes of Health (NIH), vitamin B12 hasnt been proven to cause any serious harm, even at high doses