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PTSD+MDD ( n = 7) participants had 30% higher ( p = 0.015) MPO concentrations compared to PTSD only participants ( n = 18)

Start with lower doses to assess tolerance, gradually increasing as appropriate

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Research in diet-induced obese animal models reveals tesofensine reduces body weight more effectively in obese subjects compared to lean subjects, suggesting enhanced efficacy in the metabolic conditions for which it is intended