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Of note, in the STEP 1 extension trial, participants regained roughly two-thirds of their lost weight within a year of stopping semaglutide, and improvements in blood pressure, cholesterol, and glucose largely reversed

The Limitations You Should Know: Dependency, Cost, and Side Effects Despite benefits, GLP-1 medications present challenges such as dependency, rebound weight gain upon stopping treatments, high costs especially in emerging markets, and side effects like nausea or digestive discomfort

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Celebrities ranging from Chelsea Handler, Tracy Morgan, and Oprah start coming forward and sharing that they have used Ozempic and Wegovy to lose weight

1 and 2) (see Supplementary Material for Clinical Takeaways)