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It is important to note that Phase 2 trials typically exclude participants with significant cardiovascular disease, which limits the generalisability of these safety findings to higher-risk populations

Bariatric surgery permanently reduces stomach size and removes portions of the stomach that produce intrinsic factor

The half-life of these drugs varies widely (see table below) from two weeks with the extended-release form of exenatide (Bydureon Bcise), which is injected weekly, to thirteen hours for the daily injected liraglutide (Victoza, Saxenda)

This means that to deliver equivalent therapeutic effects, oral versions require much higher doses, increasing costs and side effects while producing variable results depending on food intake, gastric pH, and individual metabolism

GLP-1 analogues have proven utility in retarding diseases development in many animal and clinical trials, which are the potential and promising drugs to be utilized in AD, hypertension, and NASH