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It is currently available in both subcutaneous and oral formulations.4 Furthermore, the impact of high doses of semaglutide on weight loss was explored in adults with overweight or obesity in the STEP programme.5 Recently, the cardiovascular benefit of high doses of semaglutide was also observed in patients with overweight or obesity at high cardiovascular risk but without T2DM.6 Despite the proven cardiovascular benefit of semaglutide, certain safety concerns still linger