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A double blinded placebo controlled study using daily Orfoglipron (45 mg) in obese patients, found an average of 12.4% decrease in body weight over placebo after 36 weeks

27 In vitro activation of the GLP-1R by exendin-4 enhanced osteogenic differentiation while inhibiting adipogenic differentiation of BMSCs

Depends on your research question

As a result of their non-systemic mode of action they are active in the gut and not absorbed into the body -glucosidase inhibitors are considered to be one of the safest and best-tolerated classes of antidiabetes agents available [18]

And the benefit had almost nothing to do with weight loss