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For severe major depressive disorder [identified using a Patient Health Questionnaire (PHQ)-9 score 20], an integrated approach combining pharmacotherapy and psychotherapy is preferred
Yet, the in vivo role of -cell KCC2, or that of KCC1, KCC3 or KCC4 on glucose homeostasis, if any, remain to be explored
J Translational Med
Understanding these risk factors helps clinicians and patients make informed decisions about supplementation strategies
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