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FIGURE 12 4.1.1 Imidazo[1,2-a] pyrazine derivatives An HTS campaign and subsequent structural optimization of Compound 37 , an initially identified PDE10A inhibitor, led to the discovery of imidazo[1,2-a] pyrazine-containing Compound 40 , a potent and selective PDE10A inhibitor exhibiting promising in vivo efficacy across various rodent behavioral models of schizophrenia, along with favorable pharmacokinetic properties in rats

Proc Natl Acad Sci USA 2004

However, a B12 supplement is usually needed if a dog is deficient in this vitamin

Wang B, Wu Y, Liu R, Xu H, Mei X, Shang Q, Liu S, Yu D, Li W (2020) Lactobacillus rhamnosus GG promotes M1 polarization in murine bone marrow-derived macrophages by activating TLR2/MyD88/MAPK signaling pathway

Featuring a quinoline ring as its core scaffold, it has a small molecular weight and excellent cell membrane permeability