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TMAO and HF HF is defined as a group of syndromes caused by structural or functional damage that results in impaired ventricular filling or cardiac output, and which involves multi-organ and systemic neurohumoral dysfunction (89)

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The 12 mg dose had higher gastrointestinal event rates and higher discontinuation due to adverse events than lower doses, emphasizing the need to balance efficacy with tolerability

Community monitoring protocols often run HbA1c at baseline and after 3-4 cycles to track cumulative glycemic impact

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