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It is not a passive fat burner and produces little without the exercise that actually moves fatty acids into the mitochondria for oxidation
PubMed PMID: 11176951
Nature Medicine , 19(5), 576-585
(Although the peptide aims to free p53 to kill senescent cells, not inhibit p53)
Mechanistically, oxidative stress activates p16-pRb effector pathway which is thought to play a vital role in SIPS mediation 11
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