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In general, the adverse event profile of a PDE5I is not worsened by a background of antihypertensive medication, even when the patient is taking several antihypertensive agents [423-425]

28 GilmanC.PerryT.FurukawaK.GriegN.EganJ.MattsonM

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Ongoing research continues to explore its potential applications in nonalcoholic fatty liver disease (NAFLD), where a 2019 trial published in Lancet HIV demonstrated a 32% relative reduction in hepatic fat fraction over 12 months