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A later review framed the molecule honestly as a still unresolved riddle, conceding that decades of study had not pinned down a mechanism or a confirmed physiological role (PMID 16539679)
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That habit is the reason I trust what I am about to tell you, because it is written down and not remembered through rose coloured glasses
Guggulsterone sensitizes glioblastoma cells to Sonic Hedgehog inhibitor SANT-1 induced apoptosis in a Ras/NFB dependent manner
However, more human research is needed
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