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However, true biotin deficiency can cause hair loss, and reduced dietary intake during GLP-1 therapy could push levels lower
Rapid hepatic metabolism blunts the endocrine action of portally infused GLP-1
IH causes mitochondrial damage, resulting in the production of mitochondrial reactive oxygen species (mtROS) and oxidized mitochondrial DNA (mtDNA), both of which activate the inflammasome (Zhou et al., In addition to mitophagy, manganese superoxide dismutase (SOD2) is a mitochondrial antioxidant enzyme that provides another source of protection against mtROS (Flynn and Melov, Overall, IH is a major contributor to inflammasome activation in immune cells
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