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Briefly, the 8-OH-dG monoclonal antibody binds competitively to the pre-coated 8-OH-dG as well as in the cell homogenate

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Brainstem preproglucagon expressing fibers project to many areas of the brain with the most abundant projections to areas hypothalamic areas that control energy homeostasis including the arcuate nucleus (ARC), paraventricular nucleus (PVN), and dorsomedial nucleus (DMH) (Jin et al., 1988)