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Glutamatergic receptor numbers, neurotransmission, and synaptic strength are all affected when the actin cytoskeleton is lost, compromising synaptic integrity (Haseena et al., 2024)
10.1080/21678421.2019.1582674 Amyotroph
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Traditional proteomics-based methods, such as N-terminomics 37,38,39 and proteomic identification of protease cleavage sites 40 , are well suited for global analyses of protease activity but can be low throughput and may lack the sensitivity to detect low-frequency, yet biologically perturbative, off-target cleavage events
Infections with Granulibacter bethesdensis (a Gram-negative rod bacterium that causes chronic necrotizing lymphadenitis and sepsis) and Burkholderia gladioli (a Gram-negative rod bacterium which can cause osteomyelitis and sepsis) should prompt evaluation for CGD
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