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In RIF, single-cell transcriptomic studies have documented persistent activation of proliferative stromal programs and incomplete progression toward mature decidual states, even in biopsies collected in the mid-luteal phase [297, 299]

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Tirzepatide and muscle volume changes in obesity (SURPASS-3 MRI substudy)

Semaglutide trials (STEP 1-4) demonstrated 15-22% weight loss over 68 weeks, while tirzepatide (SURMOUNT trials) showed 20-24% weight loss at the highest doses