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The SURMOUNT trial program, which is the largest clinical trial series evaluating tirzepatide for obesity, has produced results that have reshaped how clinicians think about medically supervised weight loss
In recent years, some people have not been able to get access to their GLP-1 RA medication because of shortages
However, regulatory approval is still pending, and further long-term data are required
In fact, GIP administration limited angiotensin II-stimulated cardiac hypertrophy and fibrosis [14]
Plans should take into account the likelihood of approval if non-formulary, considering the limited alternative options for this indication and mechanism of action
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