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When the body experiences stress, it releases hormones that can heighten bladder sensitivity and increase pain perception
The mechanism involves upregulation of tissue inhibitors of metalloproteinases (TIMPs) and simultaneous downregulation of matrix metalloproteinases (MMPs), shifting the extracellular matrix balance toward net deposition rather than degradation
Most protocols recommend 30-60 minutes before intended sleep
Normal psychological function
For those treating acne scarring, texture improvements become significant at this stage
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