Older adults, vegans and vegetarians, and people on long-term acid-reducing medication often run on the lower end of optimal range without obvious symptoms
Our results show that glutathione efflux from hepatocytes results in high local concentrations of both glutathione and cysteine in liver sinusoids, which transforms the nanoparticle surface chemistry, reduces its affinity to serum protein and significantly alters its blood retention, targeting and clearance
Simultaneously, it upregulates the expression of the transferrin receptor (TfR), intensifying iron absorption in liver cells and resulting in hepatic iron overload
NIH, National Library of Medicine, Office of Dietary Supplements - Vitamin C Fact Sheet for Health Professionals 2
For a 100 mg vial, adding 2 mL of BAC water gives a 50 mg/mL concentration